A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of hsa-miR-125b-5p
ncRNA name hsa-miR-125b-5p
ncRNA Category miRNA
Disease name diabetic retinopathy (DR)
Species Homo sapiens
Tissues/Cell_line human retinal endothelial cells (HRECs), human RPE cell line ARPE-19
Methods MTS assay, transfection, qRT-PCR, Western blot
Expression pattern down-regulated
Functional description In this study, we confirmed that miR-125b-5p was expressed at low levels in both HRECs and ARPE-19 cells under hyperglycemia exposure and in the DM retina. Therefore, modulation of miR-125b-5p in early DR might exert beneficial effects with regard to slowing DR progression and DR-associated impairment.
PubMed ID 28706953
Year 2017
Title Differentially Expressed MicroRNAs in the Development of Early Diabetic Retinopathy.
Drug-related ncRNA NO

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