|age-related macular degeneration (AMD)
|human neocortical and retinal samples
|miRNA sequencing, miRNA array
|We report the sequence and abundance of a septet of sncRNAs that are significantly increased in abundance and common to both AD-affected superior temporal lobe neocortex and the AMD-affected macular region of the retina. Their target mRNAs are involved in the synchronization of amyloid production and clearance, phagocytosis, innate-immune, pro-inflammatory, and neurotrophic signaling and/or synaptogenesis.
|Up-regulated Pro-inflammatory MicroRNAs (miRNAs) in Alzheimer's disease (AD) and Age-Related Macular Degeneration (AMD).
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