A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of hsa-miR-125b
ncRNA name hsa-miR-125b
ncRNA Category miRNA
Disease name retinoblastoma (RB)
Species Homo sapiens
Tissues/Cell_line RB tissue; RB cell lines HXO-RB44, Y79 and SO-RB50; human RPE cell line ARPE-19
Methods RT-PCR, cell migration and invasion assay, luciferase reporter assay, Western blot
Expression pattern up-regulated
Functional description miR-125b is a suppressor gene miRNA that can promote RB cell proliferation and migration by downregulating the suppressor gene DRAM2, indicating that miR-125b may represent a new potential diagnostic and therapeutic target for RB treatment.
PubMed ID 27527066
Year 2016
Title MicroRNA-125b promotes tumor growth and suppresses apoptosis by targeting DRAM2 in retinoblastoma.
Drug-related ncRNA NO

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