A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of hsa-miR-125b
ncRNA name hsa-miR-125b
ncRNA Category miRNA
Disease name cataract
Species Homo sapiens
Tissues/Cell_line anterior lens capsule; human lens epithelial cell line: SRA01/04
Methods qRT-PCR, TUNEL assay, flow cytometry, Western blot, luciferase reporter assay
Expression pattern down-regulated
Functional description miR-125b was downregulated in both age-related cataract tissue and lens epithelial cell apoptosis induced by UV irradiation. In vitro, miR-125b regulates human lens epithelial cell apoptosis at least in part by directly targeting p53.
PubMed ID 25312242
Year 2014
Title MicroRNA-125b inhibits lens epithelial cell apoptosis by targeting p53 in age-related cataract.
Drug-related ncRNA NO

Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.