A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of hsa-miR-125b
ncRNA name hsa-miR-125b
ncRNA Category miRNA
Disease name neuromyelitis optica (NMO)
Species Homo sapiens
Tissues/Cell_line blood
Methods RNA-seq
Expression pattern up-regulated
Functional description We show that expression of 17 miRNAs was significantly higher in untreated NMO patients compared with HCs (all p < 0.05). Following rituximab treatment, the expression levels of 10 of the 17 miRNAs that show increased expression in NMO reverted to the levels seen in HCs. Six of these "normalized" miRNAs are known as brain-specific/enriched miRNAs.
PubMed ID 27393339
Year 2016
Title Circulating microRNAs as biomarkers for rituximab therapy, in neuromyelitis optica (NMO).
Drug-related ncRNA YES (rituximab)

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