A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of XIST
ncRNA name XIST
ncRNA Category lncRNA
ID 7503
Ensembl ENSG00000229807
Synonyms DXS1089, DXS399E, LINC00001, NCRNA00001, swd66
Disease name retinoblastoma (RB)
Species Homo sapiens
Tissues/Cell_line RB samples, normal retinas; RB cell lines SO-RB50, Y79 and WERI-RB1; RPE cell line ARPE-19
Methods transfection, CCK-8 assay, transwell assay, flow cytometry, luciferase reporter assay, RNA immunoprecipitation (RIP), qPCR, in situ hybridization, Western blot
Expression pattern up-regulated
Functional description XIST may facilitate the progression of RB through acting as a ceRNA for miR-101 to mediate the expression of ZEB1 and ZEB2.
PubMed ID 30472203
Year 2019
Title LncRNA XIST promotes the epithelial to mesenchymal transition of retinoblastoma via sponging miR-101.
Drug-related ncRNA NO

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