A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of MEG3
ncRNA name MEG3
ncRNA Category lncRNA
ID 55384
Ensembl ENSG00000214548
Synonyms GTL2; FP504; prebp1; PRO0518; PRO2160; LINC00023; NCRNA00023; onco-lncRNA-83
Disease name diabetic retinopathy (DR)
Species Homo sapiens
Tissues/Cell_line human RPE cell line ARPE-19
Methods transfection, qRT-PCR, Western blot, luciferase assay, ELISA, MTT assay, flow cytometry
Expression pattern down-regulated
Functional description MEG3 could alleviate HG-inducing apoptosis and inflammation via inhibiting NF-κB signaling pathway by targeting miR-34a/SIRT1 axis.
PubMed ID 30529346
Year 2019
Title LncRNA-MEG3 alleviates high glucose induced inflammation and apoptosis of retina epithelial cells via regulating miR-34a/SIRT1 axis.
Drug-related ncRNA NO

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