A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of MEG3
ncRNA name MEG3
ncRNA Category lncRNA
ID 55384
Ensembl ENSG00000214548
Synonyms GTL2; FP504; prebp1; PRO0518; PRO2160; LINC00023; NCRNA00023; onco-lncRNA-83
Disease name retinoblastoma (RB)
Species Homo sapiens
Tissues/Cell_line RB samples; RB cell lines WERI-RB1 and Y79
Methods transfection, qPCR, CCK-8 assay, flow cytometry, Western blot, methylation specific PCR (MSP)
Expression pattern down-regulated
Functional description Hypermethylation of MEG3 promoter was observed more frequently in retinoblastoma tissues and was highly associated with low MEG3 expression and poor survival of retinoblastoma patients. Hypermethylation of MEG3 promoter depressed MEG3 expression, promoted proliferation, inhibited apoptosis and increased β-catenin expression of retinoblastoma cells in vitro.
PubMed ID 29287592
Year 2017
Title Hypermethylation of MEG3 promoter correlates with inactivation of MEG3 and poor prognosis in patients with retinoblastoma.
Drug-related ncRNA NO

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