A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of MEG3
ncRNA name MEG3
ncRNA Category lncRNA
ID 55384
Ensembl ENSG00000214548
Synonyms GTL2, LINC00023, NCRNA00023, onco-lncRNA-83
Disease name glaucoma
Species Homo sapiens
Tissues/Cell_line Tenon’s capsule fibroblasts; human fibroblast cell line SX1412-B
Methods MTT assay, qRT-PCR, Western blot, RNA Binding Protein immunoprecipitation (RIP)
Expression pattern down-regulated
Functional description The functional interaction between lncRNA-MEG3 and Nrf2 constitutes the mechanism by which TGF-β2 induces Tenon's capsule fibroblasts proliferation after glaucoma filtration surgery via the direct binding of MEG3 to Nrf2.
PubMed ID 28081465
Year 2017
Title Biological function and mechanism of lncRNA-MEG3 in Tenon's capsule fibroblasts proliferation: By MEG3-Nrf2 protein interaction.
Drug-related ncRNA NO

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