A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of MEG3
ncRNA name MEG3
ncRNA Category lncRNA
ID 55384
Ensembl ENSG00000214548
Synonyms GTL2; FP504; prebp1; PRO0518; PRO2160; LINC00023; NCRNA00023; onco-lncRNA-83
Disease name retinoblastoma (RB)
Species Homo sapiens
Tissues/Cell_line RB samples and corresponding nontumor tissues; Rb cell line WERI-RB1 and Y79
Methods transfection, qRT-PCR, Western blot, CCK-8 assay, apoptosis assay, luciferase reporter assay
Expression pattern down-regulated
Functional description MEG3 is a tumor suppressor by negatively regulating the activity of the Wnt/β-catenin pathway in the progression of retinoblastoma.
PubMed ID 26662307
Year 2016
Title Decreased expression of MEG3 contributes to retinoblastoma progression and affects retinoblastoma cell growth by regulating the activity of Wnt/β-catenin pathway.
Drug-related ncRNA NO

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