A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of HOTAIR
ncRNA Category lncRNA
ID 100124700
Ensembl ENSG00000228630
Synonyms HOXC-AS4, HOXC11-AS1, NCRNA00072
Disease name retinoblastoma (RB)
Species Homo sapiens
Tissues/Cell_line RB samples; RB cell lines Y79 and WERI-RB1
Methods siRNA transfection, qRT-PCR, Western blot, luciferase reporter assay, Subcutaneous xenograft
Expression pattern up-regulated
Functional description Knockdown of HOTAIR restricted the proliferation and invasion of the more invasive retinoblastoma Y79 cells, and led to G0/G1 arrest, possibly through inhibiting phospho-RB1, RB1 and CCNE. Furthermore, we found that the Notch signalling pathway was activated abnormally in retinoblastoma cell lines, while knockdown of HOTAIR attenuated the endogenous Notch signalling pathway in vitro and in vivo.
PubMed ID 27966488
Year 2016
Title Long non-coding RNA HOTAIR regulates proliferation and invasion via activating Notch signalling pathway in retinoblastoma.
Drug-related ncRNA NO

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