A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of H19
ncRNA name H19
ncRNA Category lncRNA
ID 283120
Ensembl ENSG00000130600
Synonyms ASM, ASM1, D11S813E, LINC00008, NCRNA00008
Disease name retinoblastoma (RB)
Species Homo sapiens
Tissues/Cell_line RB samples, normal retinas; RPE cell line ARPE-19; human retinal microvascular endothelial cell line (HRMEC); RB cell lines WERI-RB1 and Y79
Methods qRT-PCR, siRNA transfection, MTT assay, transwell assay, in vivo growth assay, Western blot
Expression pattern up-regulated
Functional description lncRNA H19 levels were markedly increased in retinoblastoma cells and tissues compared with corresponding controls. Patients with retinoblastoma with increased lncRNA H19 expression experienced poorer survival time compared with those with decreased lncRNA H19 levels. Knockdown of lncRNA H19 significantly suppressed retinoblastoma cell proliferation, migration and invasion.
PubMed ID 29805578
Year 2018
Title Long non-coding RNA H19 regulates viability and metastasis, and is upregulated in retinoblastoma.
Drug-related ncRNA NO

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