|ASM, ASM1, D11S813E, LINC00008, NCRNA00008
|RB samples, normal retinas; RPE cell line ARPE-19; human retinal microvascular endothelial cell line (HRMEC); RB cell lines WERI-RB1 and Y79
|qRT-PCR, siRNA transfection, MTT assay, transwell assay, in vivo growth assay, Western blot
|lncRNA H19 levels were markedly increased in retinoblastoma cells and tissues compared with corresponding controls. Patients with retinoblastoma with increased lncRNA H19 expression experienced poorer survival time compared with those with decreased lncRNA H19 levels. Knockdown of lncRNA H19 significantly suppressed retinoblastoma cell proliferation, migration and invasion.
|Long non-coding RNA H19 regulates viability and metastasis, and is upregulated in retinoblastoma.
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