A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of uveitis
ncRNA name rno-miR-34a-5p
ncRNA Category miRNA
Disease name uveitis
Species Rattus norvegicus
Tissues/Cell_line eyes
Methods Western blot, immunohistochemistry, miRNA PCR array
Expression pattern down-regulated
Functional description RvD1 dose-dependently increased the expression of sirtuin-1 (SIRT1) within the eye, while it decreased the expression of acetyl-p53 and acetyl-FOXO1. These effects were accompanied by local downregulation of some microRNAs related to the expression and activity of SIRT1. These were miR-195-5p, miR-200a-3p, miR-34a-5p, and miR-145-5p.
PubMed ID 26180376
Year 2015
Title Interplay between Intravitreal RvD1 and Local Endogenous Sirtuin-1 in the Protection from Endotoxin-Induced Uveitis in Rats.
Drug-related ncRNA YES (Resolvin D1)

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