A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of uveal melanoma (UM)
ncRNA name hsa-miR-216a-5p
ncRNA Category miRNA
Disease name uveal melanoma (UM)
Species Homo sapiens
Tissues/Cell_line human UM cell lines, human embryonic kidney cell line HEK293T; UM samples
Methods luciferase reporter assay, qRT-PCR, CCK-8 assay, colony formation assay, positron emission tomography (PET), immunohistochemistry
Expression pattern down-regulated
Functional description Our findings provide clues regarding the role of miR-216a-5p as a tumor suppressor in uveal melanoma through the inhibition of HK2.
PubMed ID 29763606
Year 2018
Title MiR-216a-5p/Hexokinase 2 axis regulates uveal melanoma growth through modulation of Warburg effect.
Drug-related ncRNA NO

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