A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of uveal melanoma (UM)
ncRNA name hsa-miR-92a-3p
ncRNA Category miRNA
Disease name uveal melanoma (UM)
Species Homo sapiens
Tissues/Cell_line UM cell lines OCM-1, OCM-3 and 92.1; UM samples, normal skin specimens
Methods qPCR, transfection, Western blot, apoptosis assay
Expression pattern down-regulated
Functional description MS-275-triggered downregulation of the oncogenic miR-92a-3p- which leads to the overexpression of its target gene MYCBP2 - is an event required for the enhanced susceptibility of melanoma cells to TRAIL-mediated apoptosis.
PubMed ID 27620505
Year 2016
Title miR-92a-3p and MYCBP2 are involved in MS-275-induced and c-myc-mediated TRAIL-sensitivity in melanoma cells.
Drug-related ncRNA NO

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