A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of uveal melanoma (UM)
ncRNA name hsa-miR-454
ncRNA Category miRNA
Disease name uveal melanoma (UM)
Species Homo sapiens
Tissues/Cell_line UM samples and their morphologically normal tissues; human UM cell lines OCM‐1A, MUM‐2C, C918 and MUM‐2B; human melanocyte cell line D78
Methods qRT-PCR, Oligonucleotide transfection, Western blot, luciferase reporter assay
Expression pattern up-regulated
Functional description Our data revealed that ectopic expression of PTEN restored the effects of miR-454 on cell proliferation and invasion in uveal melanoma cells. These findings support an oncogene role of miR-454 in development of uveal melanoma.
PubMed ID 26296312
Year 2015
Title MicroRNA-454 functions as an oncogene by regulating PTEN in uveal melanoma.
Drug-related ncRNA NO

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