A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of uveal melanoma (UM)
ncRNA name SPARC siRNA
ncRNA Category siRNA
Disease name uveal melanoma (UM)
Species Homo sapiens
Tissues/Cell_line human UM cell lines SP6.5, MKTBR and OCM-1; transformed human melanocyte cell line UW-1
Methods siRNA transfection, qPCR, proliferation assay, immunocytochemistry
Expression pattern associated
Functional description All cases of human uveal melanoma demonstrated positive staining for SPARC as did all primary and metastatic tumors from the xenograft model. The cell lines transfected with SPARC siRNA showed a significant decrease in proliferation compared to controls.
PubMed ID 19661316
Year 2009
Title SPARC is expressed in human uveal melanoma and its abrogation reduces tumor cell proliferation.
Drug-related ncRNA NO

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