A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of uveal melanoma (UM)
ncRNA name CXCR4 siRNA
ncRNA Category siRNA
Disease name uveal melanoma (UM)
Species Homo sapiens
Tissues/Cell_line human UM cell line OCM3
Methods siRNA transfection, qRT-PCR, transwell assay, histopathologic analysis
Expression pattern associated
Functional description Blocking CXCR4 gene expression by transfection with CXCR4 siRNA inhibited both the chemotactic and the invasive properties of uveal melanoma cells exposed to factors produced by human livers. Uveal melanoma cells transfected with CXCR4 siRNA produced fewer liver metastases than untreated uveal melanoma cells or uveal melanoma cells transfected with control siRNA.
PubMed ID 19553629
Year 2009
Title Inhibition of chemokine receptor expression on uveal melanomas by CXCR4 siRNA and its effect on uveal melanoma liver metastases.
Drug-related ncRNA NO

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