A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of uveal melanoma (UM)
ncRNA name hsa-miR-137
ncRNA Category miRNA
Disease name uveal melanoma (UM)
Species Homo sapiens
Tissues/Cell_line human RPE cell line ARPE-19, human normal liver cell line L‐02, human UM cell lines: SP6.5 and OM431
Methods Northern blot, qPCR, luciferase reporter assay, immunoblot, ELISA, Hoechst 33342 staining, histological analysis, TUNEL assay
Expression pattern down-regulated
Functional description To improve uveal melanoma specificity of adenovirus-based TRAIL introduction, we used miRNA response elements (MREs) of miR-34a, miR-137 and miR-182 to regulate its expression. We constructed an MRE-directed TRAIL-expressing adenoviral vector and provided evidence that this vector possessed high anti-tumor activity and uveal melanoma specificity.
PubMed ID 24001901
Year 2013
Title Tumor-targeting TRAIL expression mediated by miRNA response elements suppressed growth of uveal melanoma cells.
Drug-related ncRNA NO

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