A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of uveal melanoma (UM)
ncRNA name hsa-miR-182
ncRNA Category miRNA
Disease name uveal melanoma (UM)
Species Homo sapiens
Tissues/Cell_line human UM cell lines M23 and SP6.5; human embryonic kidney cell line HEK-293; UM samples, normal uveal tissues
Methods qRT-PCR, flow cytometry, transwell assay, Matrigel invasion assay, Hoechst staining, Caspase activity assay, luciferase reporter assay, Western blot, tumor growth assay
Expression pattern down-regulated
Functional description miR-182, a p53 dependent miRNA, suppressed the expression of MITF, BCL2, cyclin D2 and functioned as a potent tumor suppressor in uveal melanoma cells.
PubMed ID 22848417
Year 2012
Title Role of microRNA-182 in posterior uveal melanoma: regulation of tumor development through MITF, BCL2 and cyclin D2.
Drug-related ncRNA NO

Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.