A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of uveal melanoma (UM)
ncRNA name HIF-1α shRNA
ncRNA Category shRNA
Disease name uveal melanoma (UM)
Species Homo sapiens
Tissues/Cell_line human UM cell lines OCM1, Mel285, Mel290, 92.1 and OMM1
Methods shRNA knockdown, qPCR, Western blot, MTS colorimetric assay, transwell assay, immunohistochemistry
Expression pattern associated
Functional description HIF-1α knockdown using shRNA significantly decreased growth in hypoxia, and reduced by more than 50% tumor invasion in four lines with high HIF-1α baseline levels.
PubMed ID 25166211
Year 2014
Title Hypoxia promotes uveal melanoma invasion through enhanced Notch and MAPK activation.
Drug-related ncRNA NA

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