A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of uveal melanoma (UM)
ncRNA name CREB shRNA
ncRNA Category shRNA
Disease name uveal melanoma (UM)
Species Homo sapiens
Tissues/Cell_line UM cell lines OMM2.5 and Mel270
Methods shRNA knockdown, immunofluorescence, qPCR, Western blot, luciferase reporter assay, flow cytometry, cell viability assay
Expression pattern associated
Functional description We found that CREB knockdown increases the sensitivity of these cells to both DOX and DTIC in normoxia and more so in hypoxia as measured by cell survival and Caspase 3 activation.
PubMed ID 29899845
Year 2018
Title A novel combinatorial treatment option for metastatic uveal melanoma.
Drug-related ncRNA YES (doxorubicin (DOX), fotemustine or dacarbazine (DTIC))

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