A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of uveal melanoma (UM)
ncRNA name HOXA11-AS
ncRNA Category lncRNA
ID 221883
Ensembl ENSG00000240990
Synonyms HOXA-AS5, HOXA11-AS1, HOXA11AS, HOXA11S, NCRNA00076
Disease name uveal melanoma (UM)
Species Homo sapiens
Tissues/Cell_line UM samples; UM cell lines OCM-1A, MUM-2C, C918 and MUM-2B; melanocyte cell line D78
Methods qRT-PCR, transfection, CCK-8 assay, transwell assay, flow cytometry, luciferase reporter assay, Western blot, RNA immunoprecipitation, Chromatin immunoprecipitation
Expression pattern up-regulated
Functional description RNA immunoprecipitation demonstrated that HOXA11-AS could simultaneously interact with enhancer of zeste homolog 2 (EZH2) to suppress its target p21 protein expression. In addition, we demonstrated that HOXA11-AS functioned as a molecular sponge for miR-124, and overexpression of miR-124 attenuated the proliferation and invasion-promoting effect of HOXA11-AS.
PubMed ID 28749709
Year 2017
Title LncRNA HOXA11-AS Exerts Oncogenic Functions by Repressing p21 and miR-124 in Uveal Melanoma.
Drug-related ncRNA NO

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