A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of uveal melanoma (UM)
ncRNA name CANT1
ncRNA Category lncRNA
ID 124583
Ensembl ENSG00000171302
Synonyms SCAN-1, SHAPY
Disease name uveal melanoma (UM)
Species Homo sapiens
Tissues/Cell_line UM cell lines MUM2B, 92.1, OCM1, OCM1A, OM431 and SP6.5; human embryonic kidney cell line HEK293T; RPE cell line ARPE19; female uveal tissue cell line FPC1
Methods RT-PCR, qRT-PCR, transwell assay, xenograft, microarray, RNA FISH, ChOP, CHIP
Expression pattern down-regulated
Functional description CANT1 triggers the expression of JPX and FTX by directly binding to their promoters and promoting H3K4 methylation.CANT1 significantly reduced tumor metastatic capacity and tumor formation, either in cell culture or in animals harboring tumor xenograft.
PubMed ID 28330694
Year 2017
Title CANT1 lncRNA Triggers Efficient Therapeutic Efficacy by Correcting Aberrant lncing Cascade in Malignant Uveal Melanoma.
Drug-related ncRNA NO

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