A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of uveal melanoma (UM)
ncRNA name GNAQ siRNA
ncRNA Category siRNA
Disease name uveal melanoma (UM)
Species Homo sapiens
Tissues/Cell_line UM cell lines OCM1, OMM2.3 and 92.1
Methods siRNA transfection, qPCR, CCK-8 assay, Western blot, annexin-V and PI staining
Expression pattern associated
Functional description Combined treatment of siGNAQ and H101 inhibited the proliferation and activated the apoptosis of OMM2.3 and 92.1 cells by blocking the phosphorylation of MEK1/2 and increasing the phosphorylation of YAP.
PubMed ID 30320917
Year 2019
Title The oncolytic virus H101 combined with GNAQ siRNA-mediated knockdown reduces uveal melanoma cell viability.
Drug-related ncRNA NO

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