ncRNA name | CCN1 siRNA |
ncRNA Category | siRNA |
Disease name | retinopathy of prematurity (ROP) |
Species | Mus musculus |
Tissues/Cell_line | corneas |
Methods | siRNA injection, ADPase staining, immunohistochemistry, Western blot, qRT-PCR |
Expression pattern | associated |
Functional description | Intravitreal injection of CCN1 siRNA significantly reduced PI3K/Akt-VEGF pathway expression of the OIR mouse model (all P<0.05). CCN1 siRNA significantly enhanced the avascular area and avascular diameter of OIR model (P<0.05). CCN1 siRNA decreased the levels of IL-1β, IL-6, and TNF-α significantly compared to the OIR group (P<0.05). |
PubMed ID | 25995618 |
Year | 2015 |
Title | The mechanism of CCN1-enhanced retinal neovascularization in oxygen-induced retinopathy through PI3K/Akt-VEGF signaling pathway. |
Drug-related ncRNA | NO |
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