A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of retinoblastoma (RB)
ncRNA name STAT3 siRNA
ncRNA Category siRNA
Disease name retinoblastoma (RB)
Species Homo sapiens
Tissues/Cell_line human RB cell line Y79
Methods qPCR, siRNA transfection, microarray
Expression pattern associated
Functional description STAT3 inhibition by targeted siRNA suppresses the proliferation of retinoblastoma cells and the formation of in vivo orthotopic tumors. STAT3 siRNA effectively induces down-regulation of target genes of STAT3.
PubMed ID 25359779
Year 2014
Title STAT3 inhibition suppresses proliferation of retinoblastoma through down-regulation of positive feedback loop of STAT3/miR-17-92 clusters.
Drug-related ncRNA NO

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