A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of retinoblastoma (RB)
ncRNA name HIF-1α siRNA
ncRNA Category siRNA
Disease name retinoblastoma (RB)
Species Homo sapiens
Tissues/Cell_line human RB cell line Y79
Methods siRNA transfection, RT-PCR, Western blot
Expression pattern associated
Functional description Knockdown of HIF-1α by siRNAHIF-1α resulted in inhibition of cell proliferation and induced cell apoptosis in human Y-79 RB cells under both normoxic and hypoxic conditions, with hypoxic conditions being more sensitive.
PubMed ID 24860939
Year 2014
Title Inhibition of hypoxia inducible factor 1α by siRNA-induced apoptosis in human retinoblastoma cells.
Drug-related ncRNA NO

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