A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of retinoblastoma (RB)
ncRNA name hsa-miR-433
ncRNA Category miRNA
Disease name retinoblastoma (RB)
Species Homo sapiens
Tissues/Cell_line human RB cell lines Y79 and WERI-RB1
Methods qRT-PCR, luciferase reporter assay, transfection, MTT assay, Western blot
Expression pattern down-regulated
Functional description miR-433 negatively regulated RB cell proliferation, migration and invasion, and induced cell cycle arrest and apoptosis of RB cells. miR-433 regulates RB cell proliferation and metastasis through suppressing the expression of Notch1 and PAX6.
PubMed ID 27470361
Year 2016
Title MiR-433 inhibits retinoblastoma malignancy by suppressing Notch1 and PAX6 expression.
Drug-related ncRNA NO

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