A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of retinoblastoma (RB)
ncRNA name hsa-miR-125a-5p
ncRNA Category miRNA
Disease name retinoblastoma (RB)
Species Homo sapiens
Tissues/Cell_line RB samples; human RB cell lines Y79 and WERI-RB1
Methods immunohistochemistry, Western blot, microarray, qRT-PCR, luciferase reporter assay, xenograft
Expression pattern down-regulated
Functional description miR-125a-5p functions as an important tumor suppressor that suppresses the EGFR pathway by targeting TAZ to inhibit tumor progression in retinoblastoma. Thus, the miR-125a-5p/TAZ/EGFR axis may be a potential therapeutic target for retinoblastoma.
PubMed ID 27094723
Year 2016
Title Suppression of microRNA-125a-5p upregulates the TAZ-EGFR signaling pathway and promotes retinoblastoma proliferation.
Drug-related ncRNA NO

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