A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of retinoblastoma (RB)
ncRNA name p38 siRNA
ncRNA Category siRNA
Disease name retinoblastoma (RB)
Species Homo sapiens
Tissues/Cell_line human Rb cell lines: Y79 and WERI-RB1
Methods DNA fragmentation assay, [3H]Thymidine incorporation assay, DNA flurometric assay, FACS analysis, transfection, immunoblot, immunoprecipitation
Expression pattern associated
Functional description 2ME induces apoptosis in human Rb cells by causing phosphorylation of p38 Mitogen-activated protein kinase (MAPK), which appears to be correlated with phosphorlation of Bax. Both p38 specific inhibitor, SB 203580, or p38 knockdown by specific siRNA, blocked 2ME induction of Bax phosphorylation.
PubMed ID 21769948
Year 2012
Title 2-Methoxyestradiol induced Bax phosphorylation and apoptosis in human retinoblastoma cells via p38 MAPK activation.
Drug-related ncRNA YES (2-Methoxyestradiol (2ME))

Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.