A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of retinoblastoma (RB)
ncRNA name hsa-miR-204
ncRNA Category miRNA
Disease name retinoblastoma (RB)
Species Homo sapiens
Tissues/Cell_line RB samples, normal retina tissues; RB cell lines Y79, WERI‐RB‐1 and SO‐RB50
Methods qPCR, luciferase reporter assay, MTT assay, colony formation assay, migration and invasion assay, Western blot, in vivo growth assay
Expression pattern down-regulated
Functional description miR-204 was frequently downregulated in retinoblastoma tissues and cell lines. Enforced expression of miR-204 inhibited retinoblastoma cells' proliferation and invasion. CyclinD2 and MMP-9 were identified as potential targets of miR-204.
PubMed ID 25647033
Year 2015
Title MiR-204, down-regulated in retinoblastoma, regulates proliferation and invasion of human retinoblastoma cells by targeting CyclinD2 and MMP-9.
Drug-related ncRNA NO

Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.