A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of retinoblastoma (RB)
ncRNA name hsa-miR-19b
ncRNA Category miRNA
Disease name retinoblastoma (RB)
Species Homo sapiens
Tissues/Cell_line RB cell lines Y79 and WERI-RB1
Methods qPCR, flow cytometry, MTT assay, cell cytotoxicity assay
Expression pattern up-regulated
Functional description We focused on the pri-miRNA-17∼92 aptamer (pri-apt), which can potentially replace the mix of five antagomirs by one aptamer that function to abrogate the maturation of miR-17, miR-18a, and miR-19b (P<0.05) for targeting RB. Cellular changes upon transfecting the pri-apt led to S-phase arrest in WERI-RB1 cells and onset of apoptosis in both Y79 and WERI-RB1 cell lines.
PubMed ID 25513843
Year 2015
Title Blocking the maturation of OncomiRNAs using pri-miRNA-17∼92 aptamer in retinoblastoma.
Drug-related ncRNA NO

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