A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of retinoblastoma (RB)
ncRNA name Cx46 siRNA
ncRNA Category siRNA
Disease name retinoblastoma (RB)
Species Mus musculus
Tissues/Cell_line RB samples
Methods cell viability assay, xenograft, siRNA injection, Western blot
Expression pattern associated
Functional description Cx46 siRNA treated Y79 tumors had a reduced tumor volume when compared to the tumors of mice receiving the negative control siRNA or no siRNA. Knockdown of Cx46 with siRNA had an antitumor effect on human Y79 retinoblastoma tumors in the nude mouse model.
PubMed ID 21320488
Year 2011
Title Treatment with connexin 46 siRNA suppresses the growth of human Y79 retinoblastoma cell xenografts in vivo.
Drug-related ncRNA NO

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