A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of retinoblastoma (RB)
ncRNA name hsa-let-7f-1*
ncRNA Category miRNA
Disease name retinoblastoma (RB)
Species Homo sapiens
Tissues/Cell_line RB cell line Y79
Methods MTT assay, fluorescent microscope, flow cytometry, collagenase assay, microarray
Expression pattern down-regulated
Functional description Results of the microRNA analysis revealed changes in the expression of 52 miRNAs (overexpression of 6 miRNAs; downregulation of 46 miRNAs) in cells grown with PLGA–gelatin microparticles compared to those grown without microparticles. Let-7 miRNAs (let-7 family) and miR-34a may enhance retinoblastoma tumor proliferation.
PubMed ID 22690114
Year 2012
Title A novel in vitro three-dimensional retinoblastoma model for evaluating chemotherapeutic drugs.
Drug-related ncRNA NO

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