A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of retinoblastoma (RB)
ncRNA name hsa-miR-19b1
ncRNA Category miRNA
Disease name retinoblastoma (RB)
Species Homo sapiens
Tissues/Cell_line RB samples and normal retinas
Methods microarray, Northern blot, RNA-seq, Array-CGH/ROMA analyses, immunohistochemistry, immunofluorescence, histology, qRT-PCR, Western blot
Expression pattern up-regulated
Functional description We found that deletion of Rb family members led to compensatory up-regulation of the cyclin-dependent kinase inhibitor p21Cip1. miR-17~92 overexpression counteracted p21Cip1 up-regulation, promoted proliferation, and drove retinoblastoma formation.
PubMed ID 21816922
Year 2011
Title miR-17~92 cooperates with RB pathway mutations to promote retinoblastoma.
Drug-related ncRNA NO

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