A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of retinoblastoma (RB)
ncRNA name hsa-miR-181a
ncRNA Category miRNA
Disease name retinoblastoma (RB)
Species Homo sapiens
Tissues/Cell_line RB cell line Y79
Methods MTT assay, qRT-PCR, xenograft
Expression pattern associated
Functional description Gene analysis shows that miR-181a decreases the expression of anti-proliferative gene MAPK1 and anti-apoptotic gene Bcl-2, but significantly increased the expression of pro-apoptotic gene BAX. Melphalan and miR-181a have a complementary effect in reducing the viability of cultured Rb cells and decreasing Rb cell counts in an in-vivo xenograft Rb model in rats.
PubMed ID 30776396
Year 2019
Title Co-delivery of miR-181a and melphalan by lipid nanoparticles for treatment of seeded retinoblastoma.
Drug-related ncRNA YES (melphalan)

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