A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of retinoblastoma (RB)
ncRNA name hsa-miR-22a
ncRNA Category miRNA
Disease name retinoblastoma (RB)
Species Homo sapiens
Tissues/Cell_line human RB cell line Y79
Methods MTT assay, BrdU incorporation assay, qRT-PCR
Expression pattern up-regulated
Functional description To study the ability of the SD-208 as a potential anticancer agent via changing oncogene/tumor suppressor miRNAs, the researchers partially evaluated its effects on some miRNA expression. SD-208 could significantly upregulate miR-18a, 22a, and 34a (P<0.05) while downregulating miR-20a (P<0.05) expression in retinoblastoma cells.
PubMed ID 27306340
Year 2016
Title Evaluation of SD-208, a TGF-β-RI Kinase Inhibitor, as an Anticancer Agent in Retinoblastoma.
Drug-related ncRNA YES (SD-2NO8)

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