A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of retinoblastoma (RB)
ncRNA name THOR
ncRNA Category lncRNA
ID 100506797
Ensembl ENSG00000226856
Synonyms THORLNC
Disease name retinoblastoma (RB)
Species Homo sapiens
Tissues/Cell_line RB samples; human RB cell line WERI‑Rb1 and Y79; human retinal epithelial cell line ARPE-19
Methods RT-PCR, Western blot, immunoprecipitation, RNA pull down assay, MTT assay, flow cytometry, transwell assay, xenograft
Expression pattern up-regulated
Functional description LncRNA THOR is up-regulated in retinoblastoma, and its over-expression significantly enhances the malignant phenotype transformation of retinoblastoma cells through up-regulating c-myc expression via enhancing its combination with TGF2BP1 protein.
PubMed ID 30119193
Year 2018
Title LncRNA THOR acts as a retinoblastoma promoter through enhancing the combination of c-myc mRNA and IGF2BP1 protein.
Drug-related ncRNA NO

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