A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of retinoblastoma (RB)
ncRNA name CCAT1
ncRNA Category lncRNA
ID 100507056
Ensembl ENSG00000247844
Synonyms CARLO5; CARLo-5; onco-lncRNA-40
Disease name retinoblastoma (RB)
Species Homo sapiens
Tissues/Cell_line RB samples; RB cell line SO-RB50, Y79 and WERI-RB1
Methods microarray, qRT-PCR, siRNA transfection, CCK-8 assay, PI double staining, flow cytometry, Western blot, scratch wounding assay, transwell assay
Expression pattern up-regulated
Functional description LncRNA CCAT1 promotes the proliferation migration and invasion, and reduces cell apoptosis of SO-RB50 and Y79 cells, probably through negative modulation of miR-218-5p.
PubMed ID 28088735
Year 2017
Title Long non-coding RNA CCAT1 promotes human retinoblastoma SO-RB50 and Y79 cells through negative regulation of miR-218-5p.
Drug-related ncRNA NO

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