A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of retinal detachment
ncRNA name HIF-1α siRNA
ncRNA Category siRNA
Disease name retinal detachment
Species Mus musculus
Tissues/Cell_line retinas; mouse photoreceptor cell line 661W
Methods siRNA transfection and injection, Western blot, qRT-PCR, immunohistochemistry, TUNEL assay
Expression pattern associated
Functional description Silencing of HIF-1α in rat retinas prevented the detachment-induced increase in BNIP3 and LC3-II, resulting in increased PR cell death.
PubMed ID 26093278
Year 2015
Title Hypoxia inducible factor 1α contributes to regulation of autophagy in retinal detachment.
Drug-related ncRNA NO

Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.