ncRNA name | HIF-1α siRNA |
ncRNA Category | siRNA |
Disease name | retinal detachment |
Species | Mus musculus |
Tissues/Cell_line | retinas; mouse photoreceptor cell line 661W |
Methods | siRNA transfection and injection, Western blot, qRT-PCR, immunohistochemistry, TUNEL assay |
Expression pattern | associated |
Functional description | Silencing of HIF-1α in rat retinas prevented the detachment-induced increase in BNIP3 and LC3-II, resulting in increased PR cell death. |
PubMed ID | 26093278 |
Year | 2015 |
Title | Hypoxia inducible factor 1α contributes to regulation of autophagy in retinal detachment. |
Drug-related ncRNA | NO |
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