A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of retinal detachment
ncRNA name ATG5 siRNA
ncRNA Category siRNA
Disease name retinal detachment
Species Rattus norvegicus
Tissues/Cell_line retinas
Methods Western blot, immunohistochemistry, Caspase assay, TUNEL assay, siRNA injection
Expression pattern associated
Functional description Retina-RPE separation resulted in a Fas-dependent activation of autophagy, with increased Atg5 levels and intraphotoreceptor conversion of LC3-I to LC3-II. Inhibition of autophagy by 3-MA or siAtg5 accelerated the time course of caspase 8 activation and photoreceptor TUNEL staining.
PubMed ID 21421874
Year 2011
Title Autophagy activation in the injured photoreceptor inhibits fas-mediated apoptosis.
Drug-related ncRNA NO

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