A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of proliferative vitreoretinopathy (PVR)
ncRNA name PTN siRNA
ncRNA Category siRNA
Disease name proliferative vitreoretinopathy (PVR)
Species Homo sapiens
Tissues/Cell_line human RPE cell line ARPE-19
Methods immunofluorescence, siRNA transfection, CCK-8 assay, transwell assay, qPCR, Western blot, immunocytochemistry
Expression pattern associated
Functional description PTN knockdown attenuated the TGF-β1-induced migration, proliferation, cytoskeletal rearrangement, and expression of EMT markers such as α-SMA and fibronectin in the ARPE-19 cells, and these effects may have been mediated through p38 MAPK signaling pathway activation.
PubMed ID 28083679
Year 2017
Title The effects of pleiotrophin in proliferative vitreoretinopathy.
Drug-related ncRNA NO

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