A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of proliferative vitreoretinopathy (PVR)
ncRNA name MeCP2 siRNA
ncRNA Category siRNA
Disease name proliferative vitreoretinopathy (PVR)
Species Homo sapiens
Tissues/Cell_line human fetal RPE cells
Methods immunocytochemistry,immunofluorescence, MTT assay, qPCR, siRNA transfection, TUNEL assay, flow cytometry, Western blot
Expression pattern associated
Functional description We found that knock-down of MeCP2 by its specific siRNA inhibited TGFβ-induced α-SMA and FN expression. A 4-fold reduction of TGFβ-induced expression of α-SMA by MeCP2 knockdown was seen when compared with cells transfected with scrambled siRNA.
PubMed ID 26305530
Year 2015
Title Inhibition of DNA Methylation and Methyl-CpG-Binding Protein 2 Suppresses RPE Transdifferentiation: Relevance to Proliferative Vitreoretinopathy.
Drug-related ncRNA NO

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