A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of proliferative vitreoretinopathy (PVR)
ncRNA name NRD-1 siRNA
ncRNA Category siRNA
Disease name proliferative vitreoretinopathy (PVR)
Species Homo sapiens
Tissues/Cell_line primary human retina pigment epithelial (HRPEpi) cells, human RPE cell line ARPE-19
Methods RT-PCR, immunoblot, Western blot, invasion assay, ELISA, siRNA transfection
Expression pattern associated
Functional description Gene silencing of NRD-1 in ARPE/EBV cells attenuated secretion of EMT-related cytokines and expression of ADAM10 and 17 and upregulated epithelial markers.
PubMed ID 26244291
Year 2015
Title Regulation of ADAM10 and ADAM17 by Sorafenib Inhibits Epithelial-to-Mesenchymal Transition in Epstein-Barr Virus-Infected Retinal Pigment Epithelial Cells.
Drug-related ncRNA NO

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