A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of proliferative vitreoretinopathy (PVR)
ncRNA name TAK1 siRNA
ncRNA Category siRNA
Disease name proliferative vitreoretinopathy (PVR)
Species Homo sapiens
Tissues/Cell_line human RPE cell line ARPE-19
Methods ELISA, RT-PCR, siRNA transfection, immunoprecipitation, immunoblot, immunofluorescence
Expression pattern associated
Functional description The TNF-α–induced phosphorylation of p38MAPK was inhibited by siTAK1 in ARPE-19 cells. Additionally, the high level of expression of mesenchymal markers such as fibronectin and α-SMA that was caused by TNF-α treatment was reduced by siTAK1 transfection
PubMed ID 25783601
Year 2015
Title Merlin Regulates Epithelial-to-Mesenchymal Transition of ARPE-19 Cells via TAK1-p38MAPK-Mediated Activation.
Drug-related ncRNA NO

Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.