A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of proliferative vitreoretinopathy (PVR)
ncRNA name merlin siRNA
ncRNA Category siRNA
Disease name proliferative vitreoretinopathy (PVR)
Species Homo sapiens
Tissues/Cell_line human RPE cell line ARPE-19
Methods ELISA, RT-PCR, siRNA transfection, immunoprecipitation, immunoblot, immunofluorescence
Expression pattern associated
Functional description merlin exerts inhibitory effects on TNF-α-induced EMT by regulating hyaluronan endocytosis and the TAK1-p38MAPK signaling pathway. Hyaluronan endocytosis was accelerated in merlin small interfering RNA (siMerlin)-transfected cells.
PubMed ID 25783601
Year 2015
Title Merlin Regulates Epithelial-to-Mesenchymal Transition of ARPE-19 Cells via TAK1-p38MAPK-Mediated Activation.
Drug-related ncRNA NO

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