A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of proliferative vitreoretinopathy (PVR)
ncRNA name hsa-miR-34a
ncRNA Category miRNA
Disease name proliferative vitreoretinopathy (PVR)
Species Homo sapiens
Tissues/Cell_line human RPE cell line ARPE-19; human embryonic kidney cell line HEK293
Methods luciferase reporter assay, immunofluorescent staining, transwell assay, Western blot
Expression pattern down-regulated
Functional description miR-34a gene expression upregulation inhibits ARPE-19 cell proliferation, migration and adhesion partly by suppressing LGR4 expression. Both miR-34a and LGR4 are potential drug targets to prevent fibrosis in a clinical setting.
PubMed ID 27977785
Year 2016
Title LGR4 Is a Direct Target of MicroRNA-34a and Modulates the Proliferation and Migration of Retinal Pigment Epithelial ARPE-19 Cells.
Drug-related ncRNA NO

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