A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of proliferative vitreoretinopathy (PVR)
ncRNA name hsa-miR-182
ncRNA Category miRNA
Disease name proliferative vitreoretinopathy (PVR)
Species Homo sapiens
Tissues/Cell_line RPE cells; human embryonic kidney cell line HEK-293
Methods qRT-PCR, flow cytometry, transwell assay, luciferase reporter assay, Western blot
Expression pattern down-regulated
Functional description Transfection of miR-182 into RPE cells induced c-Met downregulation, which led to reduced cell proliferation and migration through declines in p-Akt formation. miR-182 downregulation along with c-Met upregulation in PVR tissues suggest that these two opposing effects play important roles in PVR development.
PubMed ID 27936052
Year 2016
Title MicroRNA-182 Suppresses HGF/SF-Induced Increases in Retinal Pigment Epithelial Cell Proliferation and Migration through Targeting c-Met.
Drug-related ncRNA NO

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