A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of proliferative vitreoretinopathy (PVR)
ncRNA name hsa-miR-21
ncRNA Category miRNA
Disease name proliferative vitreoretinopathy (PVR)
Species Homo sapiens
Tissues/Cell_line vitreous humor; human RPE cell line ARPE-19
Methods microarray, qRT-PCR, transfection, Enhanced Green Fluorescent Protein (EGFP) reporter, immunocytochemical analysis
Expression pattern up-regulated
Functional description Our studies have identified miR-21 as a potential disease-modifying miRNA in the vitreous humor that is involved in the development of retinal fibrosis and may be a novel marker of PVD.
PubMed ID 27351379
Year 2016
Title Upregulation of Mir-21 Levels in the Vitreous Humor Is Associated with Development of Proliferative Vitreoretinal Disease.
Drug-related ncRNA NO

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